DELETION OF THE LTR ENHANCER/PROMOTER HAS NO IMPACT ON THE INTEGRATION PROFILE OF MLV VECTORS IN HUMAN HEMATOPOIETIC PROGENITORS.

Deletion of the LTR enhancer/promoter has no impact on the integration profile of MLV vectors in human hematopoietic progenitors.

Moloney murine leukemia virus (MLV)-derived gamma-retroviral vectors integrate preferentially near transcriptional regulatory regions in the human genome, and are associated with a significant risk of insertional gene deregulation.Self-inactivating (SIN) vectors carry a deletion of the U3 enhancer and promoter in the long terminal repeat (LTR), and

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Tandem pore TWIK-related potassium channels and neuroprotection

TWIK-related potassium channels (TREK) belong to a subfamily of the two-pore domain potassium channels family with three members, TREK1, TREK2 and TWIK-related arachidonic acid-activated potassium channels.The two-pore domain potassium channels is the last big family of channels being discovered, therefore it is not surprising that most of the info

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Confessional State and Human Rights in Costa Rica

This paper Football - Protective - Shoulder Pads develops a historical approach to the topic of the confessional State in Costa Rica within a human rights framework.It analyzes both the context from the moment in which the conquest and colonization started, and the role played by the evangelizers to the side of the Spanish colonizers.The article an

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